Stop Melanogenesis in the skin – the underlying process of unlovely age spots.

Posted by Stephanie Duttenhaver on January 16, 2025

Melanogenesis

me·la·no·gen·e·sis

: the formation of melanin

The Mechanism of Pigmentation

There is a new advanced peptide that can disrupt and dispose of those unsightly sunspots on your face. A new, trademarked peptide can significantly brighten skin and disrupt the underlying process of unsightly skin pigmentation or melanogenesis.

What triggers melanogenesis?

Ultraviolet radiation (UVR): The main stimulus for melanogenesis, UVR from the sun activates paracrine factors (hormone secretion that affects the function of nearby cells) that start the melanogenesis signaling pathway. The purpose of this increase in melanin production is to protect the skin by absorbing UV light and preventing DNA damage.

Hormones: Studies indicate that hormonal changes can stimulate melanogenesis, e.g. the mask of pregnancy.

Inflammatory mediators: Inflammatory cytokines, such as IL-1, IL-4, and IL-6, can regulate melanogenesis. Skin inflammation can be caused by allergens, pathogens, chemical stimuli, and physical damage.

Genetics: Age, ethnicity, and other genetic factors can influence melanogenesis.

Molecules secreted by surrounding cells: Keratinocytes, fibroblasts, inflammatory, neural, or endocrine cells can secrete molecules that influence melanogenesis.

But wait, what is melanogenesis?

Melanogenesis is a complex biological process controlled by various factors, which are mainly determined by the activation of MITF - a protein that regulates the development, function, and survival of certain cells, including melanocytes. Skin pigmentation includes three major processes:

melanosome formation
melanin synthesis
melanosome transport

When pigment cells fully mature the ultimate step is to be transported and distributed to the upper skin layer, resulting in dull and pigmented skin.

Advanced peptide remodels your skin’s behavior

Fast melanin reduction and inhibition of melanosome transport and melanin generating enzymes.
Genetically diminish and inhibit melanin production and transport to surface of skin.
Engineered for fast dermal penetration for rapid results in spot fading & brightening and spot disposal: in-vivo tests within 9 days and ex-vivo tests within 14 days.

Experience it on your complexion

Sapelo’s C Skin Activator was developed to significantly reduce age spots by targeting multiple stages of melanogenesis, from enzyme production to melanosome transport. Packed with 4 of the highest quality Vitamin C’s + the melanin-busting peptide, the serum works to catalyze collagen production, hydration and brighten skin while inhibiting and breaking down old melanin. The intensive serum is formulated with multiple catalytic molecules and biologic ingredients that work together to maximize collagen activation and correct melanin imperfections. Age spots and melasma are common skin conditions but they require a significant commitment to ongoing care of your skin.

Sources and related content

Understanding the development of age spots and melasma is a complicated biological function. We have done our best to simplify it for our readers. For a deeper dive into understanding age spots, please refer to these sources:

https://my.clevelandclinic.org/health/body/22615-melanin

https://pmc.ncbi.nlm.nih.gov/articles/PMC3699939/

https://pubmed.ncbi.nlm.nih.gov/29972222/

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