Rejuvenating Cream

1.7 oz. (50 ml)

$240.00
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Our Rejuvenating Cream is engineered to improve collagen, elastin, keratin, fibroblasts, laminin and skin cell density without injury or insult to your skin--no retinoids, retinols, glycolic or salicylic acids. 

Created to safely moisturize, stabilize and revitalize skin, our proprietary formula stimulates new cells without triggering inflammation. Our cream replicates the body's immune response by mimicking the cascade of healing molecules, vitamins, minerals and micro-nutrients that your body naturally releases to repair skin after an injury. The 60+ ingredients are the catalyst for stimulating cell growth and provide the building blocks for an optimized team that supports cellular health and functionality for skin that glows with vitality. 

Our unique biochemistry: 

  • Accelerate production of collagens 1, 3, 4, 7, and 17
  • Accelerate production of elastin
  • Accelerate production of hyaluronic acid 
  • Enhances the activity of mRNA
  • Improves laminin structure 
  • Reduces inflammation from UV injury
  • Reduces glycation & rosacea

Our 6 peptides target and stimulate the growth of stronger, denser, healthier skin cells:

Key ingredients include a high concentration of six powerful peptides. Peptides offer zero benefits to skin unless there is a multitude of critical molecules surging through the extra-cellular matrix for building the new cells.

Our six (6) peptides provide a unique concentration for cell stimulation. The peptides work together encouraging cell turnover and rejuvenation without the use of any acids that dry skin and trigger an inflammatory response.

Ingredient studies have shown improvement in skin elasticity by 47%, hydration by 33% and wrinkle reduction by 61%.  

Hydration is the first cosmetic benefit of healthy skin. When applied after our Renewing Serum, the cream's 60+ purposeful and skin-building ingredients will flow effortlessly to the DEJ, giving your skin all of the building blocks it needs for optimum development, 24 hours a day.

After Renewing Serum is absorbed, apply face cream to face and neck morning and night. Follow with our Softening Emollient.

Water, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Ceteareth-20, Prunus Armeniaca (Apricot) Kernel Oil, Glycine Soja (Soybean) Oil, Cetyl Rincinoleate, Squalane Oil, Plumeria Acutifolia Flower Extract, Calendula Officinalis Flower Extract, Arnica Montana Flower Extract, Acetyl Tetrapeptide-40, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Saccharide Isomerate, Chondrus Crispus Extract, Sodium Hyaluronate, Hexapeptide 11, Pentylene Glycol, Glycerin, Hydrogenated Starch Hydrolysate, Faex (Yeast) Extract, Saccharomyces/Copper Ferment/Manganese Ferment/Zinc Ferment/Calcium Ferment/Selenium Ferment/Magnesium Ferment, Saccharomyces/Xylinum/Black Tea Ferment, Alteromonas Ferment Extract, Hydrolyzed Glycosaminoglycans, Calcium Ketogluconate, Lecithin, Ectoin, Cyclotetrapeptide-24 Aminocyclohexane Carbxylate, Hydrolyzed Hyaluronic Acid, Foeniculum Vulgare (Fennel) Seed Extract, Acetyl Tetrapeptide-5, Triticum Vulgare (Wheat) Germ Extract, Saccharomyces Lysate Extract, Mangifera Indica (Mango) Seed Butter, Behenyl Behenate, 3-O-Ethyl Ascorbic Acid, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Ceramide NP; Ceramide AP; Ceramide EOP; Phytosphingosine; Cholesterol; Sodium Lauroyl Lactylate; Carbomer, Glycereth-7 Trimethyl Ether, Honey, Oyster (Ostrea) Shell Powder, Polysorbate-60, Gardenia Jasminoides Meristem Cell Culture, Magnolia Sieboldii Extract, Butylene Glycol, Polysorbate 20, Benzyl Alcohol, Xylitol, Caprylic Acid, Propanediol, Aminomethylpropanol, Citric Acid, Sodium Citrate, Caprylyl Glycol, Xanthan Gum, Tocopherol, Parfum/Fragrance (.002% added fragrance)

Contains 2% concentration of Hyaluronic Acids

Stimulate. Build. Sustain.

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Key Bioactive Peptides

Rejuvenating Cream

Peptide Complex Benefits
Tetrapeptide-40 Reduces inflammation, inhibits collagenase activity, and improves overall collagen integrity for long-term skin resilience.
Palmitoyl Tripeptide-1 & Palmitoyl Tetrapeptide-7 Powerful anti-wrinkle complex that helps reverse UV damage, restore cellular metabolism, and support dermal repair.
Hexapeptide-11 Supports firmness, enhances wound healing, and upregulates multiple cellular functions for improved skin vitality.
Cyclotetrapeptide-24 Aminocyclohexane Carboxylate Enhances cell communication while increasing elastin, laminin, and collagen production for structural skin renewal.
Acetyl Tetrapeptide-5 Reduces puffiness and improves microcirculation, specifically targeting delicate areas prone to fluid retention.
Oligopeptide Accelerates cell turnover and stimulates renewal of younger, healthier skin cells.

Rejuvenating Cream 1.7 oz

Stimulate • Build • Sustain

AM & PM • 6 Peptides • 2 HA’s • 8 Minerals • 3 Vitamins • 3 Ceramides • 1 Stem Cell

How Peptides Work in the Skin

How Peptides Work in the Skin

Signal Peptides

Stimulates Collagen Production

↓
Zn

Carrier Peptides

Delivers Trace Minerals

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Neurotransmitter Inhibitors

Relaxes Facial Muscles

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Enzyme Inhibitors

Prevents Collagen Breakdown

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Improved Firmness
Reduced Wrinkles
Enhanced Elasticity

Rejuvenating Cream

When you’ll see results

Immediately: Skin feels softer, smoother, and more hydrated with a healthy glow.

3–7 days: Noticeable boost in hydration, balance, and overall radiance.

2–4 weeks: Improved texture, firmness, and a more refined, even look.

6–8+ weeks: Long-term improvement in skin resilience, tone, and overall quality with consistent use.

Hydration is instant. Transformation builds with time.

Sapelo Skin Care Emollient Cream 3-Step Skin Recovery System

Customer Reviews

Overall rating: 5.0 / 5 from 19 reviews.

This is the best cream. I've tried them all from ones that are triple the price at department stores to cheaper ones, but this stands out. It has literally healed my skin. I used to use another cream from a niche line but they reformulated the cream and then they discontinued it; since then I've been searching for a replacement and have done through everything until I stumbled upon this. I've tried pretty much everything from this line and the cream is my favorite thing. I'm on my 3rd bottle. Hope they never reformulate. I have super sensitive dry to normal skin. I also really love their mask, and their serum. Amazing line. For anyone struggling with their skin check this cream. It's a game changer.

Rejuvenating Cream

I have several favorite products from Sapelo Skin Care and the Rejuvenating Cream is at the top of the list. As a woman of a certain age, that also suffers from skin sensitivity and redness, I’ve found the Rejuvenating Cream to be one that calms and soothes my skin, and just feels so good. It’s truly the best!

Rejuvenating Cream

Store owner replied: Thank you, Becky! As a loyal and longtime customers, we appreciate your review. Our Rejuvenating Cream is our heroine, and we love her, too! Stephanie

The rejuvenating cream feels like putting whipped cream, light and fluffy, on my face. It makes me feel so right about the products from Sapelo. Just need a dash, another thing I learned from use. An itty bitty bit goes a long way. So happy.

Rejuvenating Cream

I love the all of the Sapelo products that I use regularly, which include the Rejuvenating Cream, the Restoring Eye Serum, and the Renewing Serum. They leave my very dry skin soft and lovely, which is a real trick in the desert environment that I live in. I also use the Softening Emollient and Anti-Aging Mask for an extra boost! I have received compliments on my skin from professional cosmetologists, who always ask what I use. I gladly share my “little secret” with them. Being a gardener who is often outdoors in an environment with high heat and harsh sun, I don’t want to play with the risks of retinol-based products, so using the Sapelo line of products keeps my skin looks so healthy and youthful without any worries.

Rejuvenating Cream

Store owner replied: Dear Emily, We thank you for your thoughtful review - which we know will be helpful for others considering Sapelo. And we thank you for your trust in our regimen! Warm regards, Stephanie

I love this luxurious cream, & the mini is great for purse or travel. Thanks

Rejuvenating Cream + MIni

Store owner replied: Dear Ruth, Thank you for taking the time to review our best-selling cream! We are delighted to hear you are enjoying the results and experience! Stephanie

Wow, this is the best cream I have ever used! It leaves my skin glowing, soft and translucent. It's worth every penny!

Rejuvenating Cream

An ad for Sapelo in a favorite magazine just caught my eye. I was not unhappy with what I was using but I was curious. After receiving a response from Stephanie and getting "educated" on what I was using vs. Sapelo and the great information I tried your products. I am amazed and grateful. Amazed at the feeling of the Seaweed Cleanser, Sea Lavender Mist and Rejuvenating Cream. Grateful for the knowledge. It didn't take long at all to know I did something wonderful for my face! Thank you. I'm sold on Sapelo.

Rejuvenating Cream

Store owner replied: Dear Laura, We continue to be grateful for the opportunity to speak with women honestly about skin care. Your open mind and willingness to listen to our philosophy on skin care is the reason I love my company and the women I meet on this journey! Thank you for taking the time to share your experience with Sapelo! Stephanie

Hands down the best moisturizer I've ever used! So silky, so heavenly, and absorbs beautifully into skin. I use it primarily at night but I have tried it under makeup and it works that way as well. Pricey but worth it.

Rejuvenating Cream

Store owner replied: Dear Victoria, thank you for your review on our Rejuvenating Cream! We love our customers and keeping them and their skin happy! Stephanie

Great cream ! Good moisturizer also!

Rejuvenating Cream

I am enjoying the skin care products I purchased from Sapelo. My face, including my necks and sensitive eye area, feels smoother and just looks better after using Sapelo products.

Rejuvenating Cream

This is by far my favorite moisturizer. A little goes a long way and I use this morning and night and one bottle lasts me above the 90+ days as stated. A little on the pricier side, but after trying other creams, this one checks off all my needs in one bottle. Light fragrance and feels very light on the face but packs a lot of moisturizer.

Rejuvenating Cream

Your creams feel so luxurious on my skin. Very thrilled with so far. Only been using about two weeks.

Rejuvenating Cream

Love it! I have sensitive skin and this is the only cream that hydrates my skin and does not bother it!

Rejuvenating Cream

This cream is a gift to my cold weather weary skin!

Rejuvenating Cream

Store owner replied: Dear Anne, Thank you so much for the feedback! With the cold weather here in Savannah, we are slathering on layer after layer of our cream! We appreciate you taking the time to send your review. Let us know if we can ever help you! Stephanie and Cindy

Skin is softer and more dewy!!

Rejuvenating Cream

This is the best cream ever! I wouldn’t be without it.

Rejuvenating Cream

Thick and creamy

Rejuvenating Cream

Store owner replied: Dear Lou, We are delighted to receive your feedback! We appreciate your business and hope that your skin is enjoying our cream as colder weather approaches! Warm regards, Stephanie

This cream is absolutely wonderful! It feels lovely as you use it, the light scent is so pretty, and it is very affective on my very difficult skin. Thank you!

Rejuvenating Cream + MIni